This product has helped our 11 year old boxer with her osteoarthritis pain significantly. The original dose did not seem adequate (some improvement in mobility but not a big difference) however so we did have to increase it. The osteoarthritis study I found used significantly higher doses than what is recommended on the ABSC bottle so we ended up needing the concentrate and her pain seems to be improved on a higher dose. If we forget a dose we can definitely tell that the stairs are much more difficult for her to navigate. I do hope the cost is lowered in the future in order to make this therapy less cost prohibitive so more animals may benefit from its use.